openalexRSC Medicinal Chemistry2021-01-01Cited by 41
Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents
Bhagyashri Rathod, Shivam Chak, Sagarkumar Patel, Amit Shard
Pyruvate kinase M2 (PKM2) catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate. It plays a central role in the metabolic reprogramming of cancer cells and is expressed in most human tumors. It is essential in indiscriminate proliferation, survival, and tackling apopt…
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