Alok Jain

Design and Synthesis of Novel Quinazolinone-Based Pyruvate Kinase M2 Activators as Selective Inhibitors of Oral Cancer Cells

Bhagyashri Rathod, Swarali Joshi, Siddulu Regu, K.V.N.S. Manikanta, Hansal Kumar, S. Dubey, et al.

Also available via: RELX Group (Netherlands)

Novel imidazopyrimidines-based molecules induce tetramerization of tumor pyruvate kinase M2 and exhibit potent antiproliferative profile

Sagarkumar Patel, Christoph Globisch, Priyanka Pulugu, Prasoon Kumar, Alok Jain, Amit Shard

Discovery of novel and potent lead molecules for the specific therapeutic targets by de novo drug design is still in infancy. Here, we disclose the unprecedented development of imidazopyri(mi)dine-based tumor pyruvate kinase M2 (PKM2) modulators by subsequent link and grow strate…Read more

Also available via: Elsevier BV

Discovery of boronic acid-based potent activators of tumor pyruvate kinase M2 and development of gastroretentive nanoformulation for oral dosing

Rajkumar Patle, Shital Shinde, Sagarkumar Patel, Rahul Maheshwari, Heena Jariyal, Akshay Srivastava, et al.

Also available via: Elsevier BV