Deep generative models are increasingly used as simulators for downstream decision-making under data scarcity, but in risk-sensitive applications their usefulness depends on rare adverse scenarios rather than typical samples. Standard generative objectives prioritize bulk distributional fidelity, leaving low-probability tails vulnerable to localized optimization noise and making tail-dependent functionals unstable under finite simulation budgets. We introduce Diachronic Sample Integration (DSI), a test-time inference framework that ensembles generated samples across checkpoints from a stochastic training trajectory. DSI targets a checkpoint-mixture distribution that averages checkpoint-specific tail fluctuations rather than relying on a single brittle endpoint. We formalize this mechanism through a finite-budget bias-variance theory. Empirically, across multivariate synthetic processes and high-frequency trading data, DSI substantially reduces tail-estimation error compared to single-checkpoint baselines under fixed simulation budgets, outperforming standard diffusion and state-of-the-art tail-aware baselines without modifying the generative objective.
The growing demand for privacy-preserving data sharing has positioned synthetic data generation as a critical component of responsible AI workflows. Despite notable advances in generative modeling, existing solutions often lack integration of adaptive generation strategies, multi…
Molecular glue degraders have emerged as a promising strategy for targeted protein degradation by inducing ternary complex formation between an E3 ubiquitin ligase and a target protein. Despite their therapeutic potential, computational design of molecular glues remains largely u…
Large generative models across text-to-text, text-to-image, and image-to-text modalities have been shown to pose significant privacy risks. One fundamental threat is membership inference attacks (MIA), which aim to determine whether a given data point was used in a model's traini…
Generative models have changed how machine learning represents complex data distributions, especially in language and vision, yet many real-world systems are observed instead as continuous, high-dimensional, and noisy sensor time series. Existing generative modeling of sensor dat…
Generative models have emerged as scalable surrogates for physical simulation, yet they offer no guarantee that their outputs respect the conservation laws, boundary conditions, and nonlinear invariants that govern the underlying physics. Constrained sampling closes this gap, enf…
Limited training data constrains deep learning models for Auditory Attention Decoding (AAD) in hearing aids (HAs). AAD uses electroencephalogram (EEG) data to decode listener's attention, enabling real-time tracking of specific sound sources. However, achieving high AAD performan…