openalexFrontiers in Immunology2026-07-23
A low-dose immunotherapy targeting Fc gamma Receptors and heparan sulfate proteoglycan to impact myeloid cells and control cancers with diverse immunosuppressive profiles
Nora Kakwata-Nkor Deluce, Elodie Creton, Alexandra Savatier, Honorine Lucchi, Laureen Bardouillet, Oscar Pereira Ramos, et al.
Myeloid cells play a key role in cancer-associated immunosuppression because their accumulation and reprogramming inhibit antitumor responses and support tumor growth. To modulate their activity, we targeted Fcγ receptors (FcγRs), which are broadly expressed in myeloid subsets. S…