openalexFrontiers in Endocrinology2026-07-24
Estetrol/drospirenone for combined oral contraception: a systematic review of efficacy, cycle control, and safety
Manuel Sánchez-Prieto, S Coll, Marina Romero-Domínguez, Marta Avella-Marcos, Mireia Castilla, Margarita Gómez del Valle, et al.
Objective To systematically evaluate the evidence on the contraceptive efficacy, cycle control, safety, and selected noncontraceptive effects of estetrol 15 mg/drospirenone 3 mg (E4/DRSP) and to assess certainty of evidence by outcome using the GRADE approach. Methods A systemati…