arxivcs.CV2026-07-14
Physically Aware Radiomics Without Interpolation: Disentangling Voxel Geometry and Signal Modification in CT and MRI
David Corral Fontecha, Juan Miranda Bautista, Pablo Menendez Fernández-Miranda, Sergio Rubio-Martín, Lara Lloret Iglesias, Jose A. Vega
Objective: Radiomic texture features are usually computed in voxel-index neighborhoods, implicitly assuming isotropic spatial relationships. In anisotropic images, this can confound voxel geometry with interpolation-induced signal changes. We developed a voxel-spacing-aware radio…