arxivq-bio.QMcs.AI2026-06-26
SVC-Probe: A Framework for Evaluating Perturbation Generalization in Spatial Foundation-Model Embeddings
Jake Y. Chen, Huu Phong Nguyen, Fuad Al Abir, Ehsan Saghapour
This work examines perturbation generalization in spatial foundation-model embeddings derived from fluorescence microscopy images. Although these models can discriminate drug conditions accurately, it remains unclear whether the learned representations reflect patterns consistent…