openalexFrontiers in Immunology2026-07-23
Dual-targeting CD73/PD-L1 bifunctional inhibitor: a promising cancer immunotherapy strategy
Jing-Jing Du, Sen Wu, Shiyun Cheng, Xiaobo Zeng, Binbin Cheng
Objectives This work aims to design and characterize a novel bifunctional small molecule that simultaneously targets PD-L1 and CD73 to enhance the therapeutic efficacy of tumor immunotherapy. Methods Multiple methodologies were integrated for compound screening and biological cha…