The expression of certain genes and proteins in brain tumors, particularly gliomas, presents potential therapeutic targets and biomarkers. One of such genes encodes the protein PINK1 (PTEN-induced Kinase 1), which has been primarily studied due to its mutations being linked to Parkinson’s disease (PD). Additionally, epidemiological studies have observed a reduced risk of developing certain types of cancer in patients with neurodegenerative diseases and vice versa. The GPR55 receptor (G protein-coupled receptor 55) exhibits pro-oncogenic properties, and its expression correlates with tumor aggressiveness and the activation of the MAPK/ERK signaling pathway. This review would aim to provide an overview of the current understanding of the relationship between PINK1 and GPR55 proteins in glioma pathophysiology and explore the potential use of plant extracts as a therapeutic alternative to regulate their expression.
Background Tuberculosis (TB) remains a global health crisis, with complex molecular mechanisms that are not fully understood. Traditional pathway analysis methods fail to capture the intricate non-linear relationships within biological networks. Methods We developed a novel artif…
Background Matrine and oxymatrine are bioactive alkaloids from Sophora species with reported anti-inflammatory and antioxidant effects in ulcerative colitis (UC). However, their overall efficacy has not been systematically evaluated. Methods Databases including PubMed, EMBASE, We…
Prostate cancer (PCa) is one of the leading causes of cancer-related mortality in men, with castration-resistant prostate cancer (CRPC) posing significant therapeutic challenges due to drug resistance mediated by the androgen receptor (AR) signaling pathway. Indolethylamine-N-met…
Background Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease (ESRD) worldwide, and renal fibrosis is a key pathological feature driving disease progression. Polyphyllin II (PPII), a steroidal saponin isolated from Rhizoma Paridis, has shown renoprotectiv…
Alcohol use disorders (AUD) are major public health issues, with a significant negative impact on the health system and the economy. Unfortunately, only a handful of pharmacotherapeutic agents are available to treat patients with AUD. Notably, these medications have limited effic…
Background Pharmacometric PK/PD models remain central to dose selection for first-in-human studies, therapeutic drug monitoring, and animal-to-human extrapolation of exposure–response relationships, but modern datasets, including digital biomarkers from continuous monitoring, omi…