Machine Learning: Using Xception, a Deep Convolutional Neural Network Architecture, to Implement Pectus Excavatum Diagnostic Tool from Frontal-View Chest X-rays

Yu-Jiun Fan, I-Shiang Tzeng, Yao-Sian Huang, Yuan-Yu Hsu, Bo-Chun Wei, Shuo-Ting Hung, Yeung-Leung Cheng

Pectus excavatum (PE), a chest-wall deformity that can compromise cardiopulmonary function, cannot be detected by a radiologist through frontal chest radiography without a lateral view or chest computed tomography. This study aims to train a convolutional neural network (CNN), a deep learning architecture with powerful image processing ability, for PE screening through frontal chest radiography, which is the most common imaging test in current hospital practice. Posteroanterior-view chest images of PE and normal patients were collected from our hospital to build the database. Among them, 80% were used as the training set used to train the established CNN algorithm, Xception, whereas the remaining 20% were a test set for model performance evaluation. The performance of our diagnostic artificial intelligence model ranged between 0.976–1 under the receiver operating characteristic curve. The test accuracy of the model reached 0.989, and the sensitivity and specificity were 96.66 and 96.64, respectively. Our study is the first to prove that a CNN can be trained as a diagnostic tool for PE using frontal chest X-rays, which is not possible by the human eye. It offers a convenient way to screen potential candidates for the surgical repair of PE, primarily using available image examinations.