Human-Inspired Framework for Robotic Craniotomy: Integrating Multimodal Fusion and Adaptive Trajectory Adjustment

Renzhen Le, Xiao Zhang, Di Wu, Yuanyu Wei, Jiachen Zhu, Zhenzhi Ying, Pengfei Zhang, Liming Shu

Manual craniotomy is a high-risk, skill-dependent procedure associated with surgeon fatigue and potential dural injury. While robotic approaches have improved safety, existing open-loop systems rely solely on preoperative images and cannot compensate for intraoperative registration errors or tissue deformation. To address this, we propose a human-inspired closed-loop robotic craniotomy framework that intelligently integrates preoperative planning with intraoperative execution. An adaptive dual-contour fusion algorithm is employed to generate trajectories that conform to complex cranial geometries while maintaining a consistent tool-bone relative pose. For intraoperative perception, a multimodal two-stage cross-modal attention block (CMA)-temporal convolutional network (TCN)-Transformer network combined with an adaptive Bayesian filter fuses force and acoustic signals to achieve robust breakthrough detection under varying bone conditions. Upon detection, an in-situ projection-based trajectory adjustment strategy dynamically compensates for depth deviations, enabling safe residual bone isolation. Experiments on bovine ribs show a breakthrough prediction accuracy of 97%, a detection latency of 0.048 +/- 0.097 s, and a maximum overshoot of 0.29 mm. All four ex vivo cranial experiments were successfully completed without dural injury. These results demonstrate that the proposed cybernetic framework enables safe and autonomous craniotomy with highly effective closed-loop control.