Modeling tissue states and their transitions is essential for understanding tissue homeostasis in health and pathological remodeling in disease. However, conventional computational modeling approaches are inadequate to capture the complexity of tissues as spatially organized, multiscale biological systems. Artificial intelligence (AI) has shown a remarkable ability for representing intricate systems, creating new opportunities to characterize tissue states and their transitions. Here, we propose the concept of AI virtual tissue (AIVT), an AI framework grounded in spatial multimodal data for modeling tissues in health and disease. AIVT is designed to learn unified, spatially resolved, and dynamically manipulatable representations of tissue state, enabling tissue state representation and analysis, molecular and morphological feature prediction, and simulation of spatiotemporal tissue dynamics. We outline the fundamental assumptions, core capabilities, architectural components, as well as data and algorithm foundations of AIVT as a framework for AI-driven tissue modeling.
We present WorldDirector, a highly controllable video world model framework designed for persistent dynamic object memory and unrestricted viewpoint exploration. Unlike existing world models that entangle physical dynamics with pixel rendering and rely on continuous visual observ…
Unmanned Aerial Vehicle (UAV) object tracking has emerged as a popular research field with broad practical applications. Modern UAVs are increasingly equipped with both visible light and thermal infrared sensors. However, due to constraints in communication bandwidth, computation…
Multivariate time-series models for prognostics are often evaluated by point prediction accuracy, yet their internal states rarely expose a coherent degradation process. We study liquid neural networks as latent dynamics models for aircraft engine health monitoring on the C-MAPSS…
Multimodal LLMs struggle to systematically model the temporal evolution of visual scenes in videos or multi-image sequences. Such inputs require models to predict or simulate multiple levels of dynamic constituents, such as actions taken in the visual sequence, and the associated…
Simulating deformable objects is essential for a wide range of robotic manipulation applications, yet accurately predicting their dynamics remains challenging. We propose Physics-Guided Residual Dynamics (PGRD), a hybrid simulation framework that combines the advantages of physic…