Antibodies are essential therapeutic molecules, and their complementarity-determining regions (CDRs) form the primary antigen-recognition interface. Recent protein generative models have demonstrated broad capabilities in biomolecular design, yet post-training strategies for downstream objectives remain limited. Standard denoising training operates on noisy states obtained by perturbing native structures, whereas recursive generation proceeds through model-generated intermediate states. For flexible antibody CDR loops such as CDR-H3, this mismatch can allow backbone deviations to accumulate along the denoising trajectory and compromise antigen-facing loop geometry. We introduce ABOPD, an antibody design framework based on on-policy distillation that leverages privileged native geometry during training to supervise states visited along the model's own denoising trajectories. With this fine-grained structural supervision, ABOPD substantially improves structural recovery on RAbD CDR-H3 generation, reducing RMSD by 0.42 Å (from 2.37 Å to 1.95 Å) and outperforming supervised fine-tuning and offline distillation controls, offering a path to higher-fidelity protein design.
Open-weight language models from different families exhibit complementary capabilities, motivating their consolidation into a compact student through on-policy distillation (OPD). However, full-vocabulary OPD typically assumes a shared tokenizer, while existing cross-tokenizer me…
Reinforcement learning with verifiable rewards (RLVR) is a powerful recipe for improving language-model reasoning, but it is expensive to repeat on every new strong model because the target model must generate many rollouts during training. As models scale, post-training itself b…
On-policy distillation is a powerful way to transfer reasoning ability from a strong teacher to a smaller student: the student samples trajectories from its own policy, and the teacher provides dense token-level supervision on the states the student actually visits. However, this…
On-policy knowledge distillation transfers reasoning from large teachers to compact students, but existing approaches suffer three compounding failure modes: (i) cold-start collapse, where a fresh student assigns near-zero mass to teacher-preferred tokens; (ii) state-agnostic div…
We study on-policy distillation (OPD) for agentic tasks, where an LLM agent interacts with an environment over multiple turns and a student imitates a teacher over these multi-turn interaction histories. Fully online OPD is costly because each update requires fresh student rollou…
Off-policy distillation is now central to large language model pre-training, yet how training data, objective parameterization, and model capabilities interact remains poorly characterized. We studies top-$k$-truncated, temperature-scaled off-policy distillation by decomposing th…