openalexNature Communications2026-07-23
Structure-based design of stable recombinant hepatitis C virus E1E2 heterodimers
Joan Capella-Pujol, Fabian Mulder, Fabien Cannac, Stan Peters, Maddy L. Newby, Meliawati Poniman, et al.
Abstract Hepatitis C virus (HCV) affects 47 million people and causes 239,000 deaths annually, yet no vaccine is on the horizon. Generating a stable native-like mimic of the envelope complex E1E2, the only target for known neutralizing antibodies, is an important aim for HCV vacc…