openalexNature Communications2026-07-23
Polymorphic IGLV6-57 AL amyloid fibrils and features of a shared folding pathway
Parker Bassett, Binh A. Nguyen, Virender Singh, Patrick T. Garrett, James J. Moresco, Joshua Eddy, et al.
Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by the misfolding and aggregation of free immunoglobulin light chains (LCs) secreted by abnormal plasma cells. The resulting amyloid fibrils deposit in multiple organs, leading to progressive dysfunction an…